Cardiac t-tubules: where structural plasticity meets functional adaptation
نویسندگان
چکیده
منابع مشابه
Structure of Cardiac T-Tubules
action potential through the heart. During the cardiac action potential, Ca2+ enters each cardiac myocyte through L-type Ca2+ channels [as the Ca2+ current (ICa)] and activates adjacent Ca2+ release channels [ryanodine receptors (RyR)] in the membrane of the intracellular Ca2+ store, the sarcoplasmic reticulum (SR), causing Ca2+ release from the SR (5). Ventricular myocytes, which cause contrac...
متن کاملStructure of Cardiac T-Tubules
action potential through the heart. During the cardiac action potential, Ca2+ enters each cardiac myocyte through L-type Ca2+ channels [as the Ca2+ current (ICa)] and activates adjacent Ca2+ release channels [ryanodine receptors (RyR)] in the membrane of the intracellular Ca2+ store, the sarcoplasmic reticulum (SR), causing Ca2+ release from the SR (5). Ventricular myocytes, which cause contrac...
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BACKGROUND Phosphoinositide 3-kinases (PI3Ks) regulate numerous physiological processes including some aspects of cardiac function. Although regulation of cardiac contraction by individual PI3K isoforms has been studied, little is known about the cardiac consequences of downregulating multiple PI3Ks concurrently. METHODS AND RESULTS Genetic ablation of both p110α and p110β in cardiac myocytes...
متن کاملThe functional role of cardiac T-tubules explored in a model of rat ventricular myocytes.
The morphology of the cardiac transverse-axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. The geo...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2016
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvw198